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Antimicrobial Agents and Chemotherapy, November 1999, p. 2787-2789, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Differential Modulatory Effects of Clarithromycin on the Production of Cytokines by a Tumor

Kazuhiko Sassa,1 Yutaka Mizushima,1,2,* and Masashi Kobayashi1

First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0152,1 and Department of Geriatrics, Hirosaki University School of Medicine, Hirosaki 036-8562,2 Japan

Received 5 April 1999/Returned for modification 2 June 1999/Accepted 20 August 1999

In vitro treatment with clarithromycin inhibited the expression of the matrix metalloproteinase-9, transforming growth factor beta , and tumor necrosis factor alpha genes in 13762NF rat mammary adenocarcinoma cells. Transient enhancement, rather than inhibition, was observed for the interleukin-6 gene, and no significant change was observed for the tissue inhibitor of metalloproteinase-2 gene. Such an effect was not observed for cefotiam or gentamicin.

* Corresponding author. Mailing address: Department of Geriatrics, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan. Phone: 81-172-33-5111, ext. 6424. Fax: 81-172-39-5346.

Antimicrobial Agents and Chemotherapy, November 1999, p. 2787-2789, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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