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Antimicrobial Agents and Chemotherapy, November 1999, p. 2811-2812, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Effects of F171 Mutations in the 6'-N-Acetyltransferase Type Ib [AAC(6')-Ib] Enzyme on Susceptibility to Aminoglycosides

Ramona Chavideh, Steven Sholly, Doina Panaite, and Marcelo E. Tolmasky*

Institute of Molecular Biology and Nutrition, Department of Biological Science, School of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, California 92834-6850

Received 12 April 1999/Returned for modification 29 June 1999/Accepted 17 August 1999

Substitutions at position F171 of 6'-N-acetyltransferase type Ib cause variable loss of aminoglycoside resistance, indicating that this residue plays an important role in the structure and/or function of the enzyme.

* Corresponding author. Mailing address: Department of Biological Science, School of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, CA 92834-6850. Phone: (714) 278-5263. Fax: (714) 278-3426. E-mail: mtolmasky{at}fullerton.edu.

Antimicrobial Agents and Chemotherapy, November 1999, p. 2811-2812, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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