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Antimicrobial Agents and Chemotherapy, November 1999, p. 2817-2818, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Azithromycin Activities against Orientia tsutsugamushi Strains Isolated in Cases of Scrub Typhus in Northern Thailand

George Watt,1,* Pacharee Kantipong,2 Krisada Jongsakul,1 Pochaman Watcharapichat,3 and Duangporn Phulsuksombati3

Department of Retrovirology, U.S. Army Component,1 and Analytical Division, Royal Thai Army Component,2 AFRIMS, Bangkok, and Department of Medicine, Chiangrai Regional Hospital, Chiangrai,3 Thailand

Received 29 January 1999/Accepted 25 August 1999

Azithromycin was given to mice and humans infected with strains of Orientia tsutsugamushi from northern Thailand, where drug-resistant scrub typhus occurs. Azithromycin and doxycycline yielded comparable mouse survival rates (73 and 79%, respectively; P > 0.5). Symptoms, signs, and fever in two pregnant women abated rapidly with azithromycin. Prospective human trials are needed.

* Corresponding author. Mailing address: HIV Interaction Section, Department of Retrovirology, USAMC-AFRIMS, APO, AP 96546. Phone: (662) 644-6735. Fax: (662) 246-8908. E-mail: LTC-George_Watt{at}WRSMTP.CCMAIL.ARMY.MIL.

Antimicrobial Agents and Chemotherapy, November 1999, p. 2817-2818, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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