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Antimicrobial Agents and Chemotherapy, December 1999, p. 3005-3007, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Oral Bioavailability and Pharmacokinetics of Trovafloxacin in Patients with AIDS

Melinda K. Lacy,1 David P. Nicolau,2,3,* Charles H. Nightingale,2,4 Amy Geffken,5 Renli Teng,5 John Vincent,5 and Richard Quintiliani4

Department of Pharmacy Practice, University of Kansas Medical Center, Kansas City, Kansas 661601; Department of Pharmacy Research,2 Office for Research Administration,4 and Division of Infectious Diseases,3 Hartford Hospital, Hartford, Connecticut 06102; and Pfizer Central Research, Groton, Connecticut 063405

Received 22 March 1999/Returned for modification 24 July 1999/Accepted 8 September 1999

Trovafloxacin pharmacokinetics were evaluated in 12 subjects with AIDS. By using a randomized design, single 200-mg doses of oral trovafloxacin and intravenous alatrofloxacin were administered. The mean absolute bioavailability was 91%. The pharmacokinetics of trovafloxacin when administered orally as the active form or intravenously as the prodrug (alatrofloxacin) are not altered in subjects with AIDS compared to those in healthy adults.

* Corresponding author. Mailing address: Division of Infectious Diseases, Hartford Hospital, Hartford, CT 06102. Phone: (860) 545-3941. Fax: (860) 545-5112. E-mail: dnicola{at}harthosp.org.

Antimicrobial Agents and Chemotherapy, December 1999, p. 3005-3007, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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