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Antimicrobial Agents and Chemotherapy, December 1999, p. 3008-3010, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

High-Level Aminoglycoside Resistance in the Beta-Hemolytic Group G Streptococcus Isolate BM2721

Marc Galimand,1,* Thierry Lambert,2 Guy Gerbaud,1 and Patrice Courvalin1

Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15,1 and Centre d'Etudes Pharmaceutiques, 92296 Châtenay-Malabry,2 France

Received 12 July 1999/Returned for modification 17 August 1999/Accepted 17 September 1999

The beta-hemolytic group G Streptococcus clinical isolate BM2721 was resistant to high levels of aminoglycosides by synthesis of AAC(6')-APH(2"), APH(3')-III, and ANT(6) modifying enzymes. The corresponding genes were found to be adjacent as the result of a recombination event between Tn4001 and Tn5405, two transposons originating in staphylococci.

* Corresponding author. Mailing address: Unité des Agents Antibactériens, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France. Phone: (33) (1) 45 68 83 18. Fax: (33) (1) 45 68 83 19. E-mail: galimand{at}pasteur.fr.

Antimicrobial Agents and Chemotherapy, December 1999, p. 3008-3010, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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