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Antimicrobial Agents and Chemotherapy, December 1999, p. 3011-3013, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Characterization of a Mycobacterium smegmatis Mutant Lacking Penicillin Binding Protein 1

Helen Billman-Jacobe,* Ruth E. Haites, and Ross L. Coppel

Department of Microbiology, Monash University, Clayton, Victoria 3168, Australia

Received 19 July 1999/Returned for modification 24 August 1999/Accepted 23 September 1999

The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of ponA in M. smegmatis resulted in a PBP1-deficient mutant that was sensitive to beta -lactam antibiotics, was more permeable to glycine, and grew slowly in liquid culture.

* Corresponding author. Mailing address: Department of Microbiology, Monash University, Wellington Rd., Clayton, Victoria 3168, Australia. Phone: 61 3 9905 4842. Fax: 61 3 9905 4811. E-mail: Helen.BJ{at}med.monash.edu.au.

Antimicrobial Agents and Chemotherapy, December 1999, p. 3011-3013, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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