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Antimicrobial Agents and Chemotherapy, December 1999, p. 3022-3024, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Antimicrobial Resistance of Diarrheagenic Escherichia coli Isolated from Children under the Age of 5 Years from Ifakara, Tanzania

Jordi Vila,1,* Martha Vargas,1 Climent Casals,1 Honorato Urassa,2 Hassan Mshinda,2 David Schellemberg,2 and Joaquim Gascon1

Departament de Microbiologia, Hospital Clinic, IDIBAPS (Institut d'Investigacions Biomèdiques August Pí i Sunyer), Barcelona 08036, Spain,1 and Ifakara Health Research and Development Centre, National Institute for Medical Research, Ifakara, Tanzania2

Received 15 June 1999/Returned for modification 16 August 1999/Accepted 2 October 1999

Diarrhea caused by multidrug-resistant bacteria is an important public health problem among children in developing countries. The prevalence and antimicrobial susceptibility of diarrheagenic Escherichia coli in 346 children under 5 years of age in Ifakara, Tanzania, were studied. Thirty-eight percent of the cases of diarrhea were due to multiresistant enterotoxigenic E. coli, enteroaggregative E. coli, or enteropathogenic E. coli. Strains of all three E. coli categories showed high-level resistance to ampicillin, tetracycline, co-trimoxazole, and chloramphenicol but were highly susceptible to quinolones. Guidelines for appropriate use of antibiotics in developing countries need updating.

* Corresponding author. Mailing address: Laboratori de Microbiologia, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain. Phone: 34.93.2275522. Fax: 34.93.2275454. E-mail: vila{at}medicina.ub.es.

Antimicrobial Agents and Chemotherapy, December 1999, p. 3022-3024, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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