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Antimicrobial Agents and Chemotherapy, December 1999, p. 3033-3035, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Beneficial Effect of Adjunctive Azithromycin in Treatment of Mucoid Pseudomonas aeruginosa Pneumonia in the Murine Model

David P. Nicolau,1,2,* Mary Anne Banevicius,1 Charles H. Nightingale,3 and Richard Quintiliani3

Department of Pharmacy Research1 and Division of Infectious Diseases,2 Office of Research Administration,3 Hartford Hospital, Hartford, Connecticut 06102

Received 1 June 1999/Returned for modification 16 August 1999/Accepted 2 October 1999

While a time-kill methodology noted no appreciable improvement in bactericidal activity with the addition of azithromycin (AZM) to a ceftazidime (CAZ) regimen, data from the murine pneumonia model showed that the addition of AZM significantly improved survival compared to treatment with CAZ alone. These data suggest that AZM might be a useful adjunctive therapy in the management of pneumonia resulting from mucoid isolates of Pseudomonas aeruginosa.

* Corresponding author. Mailing address: Division of Infectious Diseases, Hartford Hospital, 80 Seymour St., Hartford, CT 06102. Phone: (860) 545-3941. Fax: (860) 545-3992. E-mail: dnicola{at}harthosp.org.

Antimicrobial Agents and Chemotherapy, December 1999, p. 3033-3035, Vol. 43, No. 12
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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