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Antimicrobial Agents and Chemotherapy, February 1999, p. 371-373, Vol. 43, No. 2
0066-4804/99/$00.00+0

Fungal Lethality, Binding, and Cytotoxicity of Syringomycin-E

A. J. De Lucca,1,* T. J. Jacks,1 J. Takemoto,2 B. Vinyard,3 J. Peter,4 E. Navarro,4 and T. J. Walsh4

Southern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, New Orleans, Louisiana1; Department of Biology, Utah State University, Logan, Utah2; Biometrical Consulting Service, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland3; and Immunocompromised Host Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland4

Received 13 January 1998/Returned for modification 21 May 1998/Accepted 4 December 1998

Syringomycin-E (SE) was significantly lethal to Aspergillus and Fusarium species at between 1.9 and 7.8 µg/ml. SE complexed with the following fungal wall constituents (in order of binding): beta -1,3-glucan > chitin > mannan > ergosterol = cholesterol. Cytotoxicity in HeLa cells was proportional to the SE concentration, while the amount required for cytotoxicity was 3 to 20 times that needed to kill 95% of the fungi tested.

* Corresponding author. Mailing address: Southern Regional Research Center, 1100 Robert E. Lee Blvd., New Orleans, LA 70124. Phone: (504) 286-4253. Fax: (504) 286-4419. E-mail: adelucca{at}nola.srrc.usda.gov.

Antimicrobial Agents and Chemotherapy, February 1999, p. 371-373, Vol. 43, No. 2
0066-4804/99/$00.00+0




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