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Antimicrobial Agents and Chemotherapy, February 1999, p. 374-376, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Mutations in 23S rRNA in Helicobacter pylori Conferring Resistance to Erythromycin Do Not Always Confer Resistance to Clarithromycin

M. Isabel García-Arata,1,* Fernando Baquero,1 Luis de Rafael,1 Carlos Martín de Argila,2 Javier P. Gisbert,2 Fernando Bermejo,2 Daniel Boixeda,2 and Rafael Cantón1

Departments of Microbiology1 and Gastroenterology,2 Hospital Ramón y Cajal, 28034 Madrid, Spain

Received 25 June 1998/Returned for modification 2 September 1998/Accepted 4 December 1998

Mutations conferring resistance to erythromycin or clarithromycin in Helicobacter pylori were studied. Mutation A2142G was consistently associated with clarithromycin MIC of >256 µg/ml, whereas mutants carrying A2143G had MICs ranging from <= 0.016 to >256 µg/ml, suggesting that additional factors account for the observed multiple levels of resistance to clarithromycin.

* Corresponding author. Mailing address: Hospital Ramón y Cajal, Department of Microbiology, Carretera de Colmenar km 9.1, 28034 Madrid, Spain. Phone: (34) 91 336 83 30. Fax: (34) 91 336 88 09. E-mail: mloboa{at}meditex.es.

Antimicrobial Agents and Chemotherapy, February 1999, p. 374-376, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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