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Antimicrobial Agents and Chemotherapy, February 1999, p. 390-392, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Activity of a Heat-Induced Reformulation of Amphotericin B Deoxycholate (Fungizone) against Leishmania donovani

C. Petit,1 V. Yardley,2 F. Gaboriau,1,* J. Bolard,1 and S. L. Croft2

Laboratoire de Physicochimie Biomoléculaire et Cellulaire (CNRS ESA 7033), Université Pierre et Marie Curie, 75252 Paris cedex 05, France,1 and Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom2

Received 17 June 1998/Returned for modification 4 September 1998/Accepted 2 November 1998

The heat treatment of amphotericin B deoxycholate (Fungizone), which was previously shown to induce superaggregation and decrease the toxicity of the drug to mammalian cells, increased its activity against Leishmania donovani in BALB/c mice, whereas it reduced its toxicity. Heat treatment preserved the activity of Fungizone against L. donovani HU3-infected mouse peritoneal macrophages.

* Corresponding author. Present address: Groupe de Recherche en Thérapeutique Anticancéreuse (CNRS ESA 6027), Université Rennes 1, Faculté de Médecine, 2 Avenue du Professeur Léon Bernard 35043 Rennes cedex, France. Phone: (2) 99 33 62 69. Fax: (2) 99 33 68 99. E-mail: Francois.Gaboriau{at}univ-rennes1.fr.

Antimicrobial Agents and Chemotherapy, February 1999, p. 390-392, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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