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Antimicrobial Agents and Chemotherapy, February 1999, p. 393-396, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Diversification of Escherichia coli Expressing an SHV-Type Extended-Spectrum beta -Lactamase (ESBL) during a Hospital Outbreak: Emergence of an ESBL-Hyperproducing Strain Resistant to Expanded-Spectrum Cephalosporins

Andrzej Palucha,1 Barbara Mikiewicz,2 and Marek Gniadkowski1,*

Sera and Vaccines Central Research Laboratory, 00-725 Warsaw,1 and Health Care Center Praga-Pólnoc, 03-719 Warsaw,2 Poland

Received 18 May 1998/Returned for modification 7 September 1998/Accepted 5 November 1998

Twelve SHV-type extended-spectrum beta -lactamase (ESBL)-producing Escherichia coli lac mutant isolates were recovered in October 1997 from 11 patients of the neonatal ward in a Warsaw hospital. The outbreak was clonal; however, some of the isolates expressed a much higher level of resistance to several beta -lactam antibiotics, including expanded-spectrum cephalosporins. This phenotype has been attributed to beta -lactamase hyperproduction correlating with the multiplication of ESBL gene copies, as was demonstrated for representative isolates.

* Corresponding author. Mailing address: Sera and Vaccines Central Research Laboratory, ul. Chelmska 30/34, 00-725 Warsaw, Poland. Phone: (48) 22-651 46 70. Fax: (48) 22-41 29 49. E-mail: marekg{at}ibbrain.ibb.waw.pl.

Antimicrobial Agents and Chemotherapy, February 1999, p. 393-396, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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