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Antimicrobial Agents and Chemotherapy, February 1999, p. 397-399, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Resistance of Pseudomonas aeruginosa to Imipenem Induced by Eluates from Siliconized Latex Urinary Catheters Is Related to Outer Membrane Protein Alterations

Luis Martínez-Martínez,1,* Alvaro Pascual,1 María del Carmen Conejo,1 Leandro Picabea,2 and Evelio J. Perea1

Department of Microbiology, School of Medicine, University of Seville,1 and Forensic Science Institute,2 Seville, Spain

Received 13 April 1998/Returned for modification 29 July 1998/Accepted 6 November 1998

The activity of imipenem against Pseudomonas aeruginosa HUS-3 decreased by 16 times in the presence of substances eluted from siliconized latex urinary catheters (SLUCs). SLUCs did not inactivate imipenem or increase beta -lactamase activity. The outer membrane of P. aeruginosa HUS-3 grown in the presence of eluate lacked an OprD-like protein and expressed a new 50-kDa protein. The decreased activity of imipenem against P. aeruginosa in the presence of SLUCs is related to the loss of an OprD-like protein and the expression of a new outer membrane protein.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, Apdo 914, 41080 Seville, Spain. Phone: 34-95-4557448. Fax: 34-95-4377413. E-mail: lmartin{at}cica.es.

Antimicrobial Agents and Chemotherapy, February 1999, p. 397-399, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.