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Antimicrobial Agents and Chemotherapy, February 1999, p. 403-405, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Mycobacteriocidal Action of Exogenous Nitric
Oxide
Richard
Long,1,*
Bruce
Light,2 and
James A.
Talbot3
Departments of
Medicine1 and
Medical Microbiology and
Immunology,3 University of Alberta, Edmonton,
and
Department of Medicine, University of Manitoba,
Winnipeg,2 Canada
Received 29 June 1998/Returned for modification 2 October
1998/Accepted 12 November 1998
We tested the hypothesis that exposure of extracellular
Mycobacterium tuberculosis to low concentrations (<100
ppm) of nitric oxide (NO) for short periods (24 h or less) will result
in microbial killing. We observed that NO had both dose- and
time-dependent cidal effects that were very significant by two-way
analysis of variance (F ratios of 13.4 [P < 0.001] and 98.1 [P < 0.0001], respectively).
Conceivably, extracellular bacilli in patients with pulmonary
tuberculosis might be vulnerable to exogenous NO.
*
Corresponding author. Mailing address: University of
Alberta Hospitals, Room 2E4.21, Walter Mackenzie Centre, 8440 112nd
St., Edmonton, Alberta, Canada T6G 2B7. Phone: (403) 492-7551. Fax: (403) 492-6384. E-mail: richardlong{at}health.gov.ab.ca.
Antimicrobial Agents and Chemotherapy, February 1999, p. 403-405, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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