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Antimicrobial Agents and Chemotherapy, February 1999, p. 403-405, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Mycobacteriocidal Action of Exogenous Nitric Oxide

Richard Long,1,* Bruce Light,2 and James A. Talbot3

Departments of Medicine1 and Medical Microbiology and Immunology,3 University of Alberta, Edmonton, and Department of Medicine, University of Manitoba, Winnipeg,2 Canada

Received 29 June 1998/Returned for modification 2 October 1998/Accepted 12 November 1998

We tested the hypothesis that exposure of extracellular Mycobacterium tuberculosis to low concentrations (<100 ppm) of nitric oxide (NO) for short periods (24 h or less) will result in microbial killing. We observed that NO had both dose- and time-dependent cidal effects that were very significant by two-way analysis of variance (F ratios of 13.4 [P < 0.001] and 98.1 [P < 0.0001], respectively). Conceivably, extracellular bacilli in patients with pulmonary tuberculosis might be vulnerable to exogenous NO.

* Corresponding author. Mailing address: University of Alberta Hospitals, Room 2E4.21, Walter Mackenzie Centre, 8440 112nd St., Edmonton, Alberta, Canada T6G 2B7. Phone: (403) 492-7551. Fax: (403) 492-6384. E-mail: richardlong{at}health.gov.ab.ca.

Antimicrobial Agents and Chemotherapy, February 1999, p. 403-405, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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