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Antimicrobial Agents and Chemotherapy, February 1999, p. 413-414, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

An Alternative Animal Model for Comparison of Treatments for Cryptococcal Meningitis

Laura K. Najvar,1 Rosie Bocanegra,1 and John R. Graybill1,2,*

Veterans Administration Hospital2 and University of Texas Health Science Center,1 San Antonio, Texas

Received 24 July 1998/Returned for modification 14 September 1998/Accepted 6 November 1998

Weanling outbred rats were infected with Cryptococcus neoformans by direct percranial puncture and inoculation into the cranium. A lethal infection ensued. Treatment with LY295337, a depsipeptide with antifungal activity, was effective in prolonging survival and reducing fungal counts in brain tissue. Weanling rats are an acceptable model for the study of central nervous system infection with C. neoformans.

* Corresponding author. Mailing address: Division of Infectious Diseases, Audie Murphy VA Hospital, 7400 Merton Minter Blvd., San Antonio, TX 78284. Phone: (210) 617-5111. Fax: (210) 614-6197. E-mail: graybill{at}uthscsa.edu.

Antimicrobial Agents and Chemotherapy, February 1999, p. 413-414, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Kirkpatrick, W. R., Najvar, L. K., Bocanegra, R., Patterson, T. F., Graybill, J. R. (2007). New Guinea Pig Model of Cryptococcal Meningitis. Antimicrob. Agents Chemother. 51: 3011-3013 [Abstract] [Full Text]  
  • Fries, B. C., Lee, S. C., Kennan, R., Zhao, W., Casadevall, A., Goldman, D. L. (2005). Phenotypic Switching of Cryptococcus neoformans Can Produce Variants That Elicit Increased Intracranial Pressure in a Rat Model of Cryptococcal Meningoencephalitis. Infect. Immun. 73: 1779-1787 [Abstract] [Full Text]  


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