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Antimicrobial Agents and Chemotherapy, February 1999, p. 418-420, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro Activities of Benflumetol against 158 Senegalese Isolates of Plasmodium falciparum in Comparison with Those of Standard Antimalarial Drugs

Bruno Pradines,1,* Adama Tall,2 Thierry Fusai,1 Andre Spiegel,2 Remi Hienne,1 Christophe Rogier,1 Jean Francois Trape,3 Jacques Le Bras,4 and Daniel Parzy1

Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, Marseille,1 and Centre National de Référence de la Chimiosensibilité du Paludisme, Hôpital Bichat, Paris,4 France, and Service d'Epidémiologie, Institut Pasteur,2 and Laboratoire de Paludologie, ORSTOM,3 Dakar, Sénégal

Received 26 August 1998/Returned for modification 20 October 1998/Accepted 13 November 1998

The 50% inhibitory concentration (IC50s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). No correlation or weak correlations in the responses to benflumetol and pyrimethamine, chloroquine, amodiaquine, artemether, quinine, and pyronaridine were observed, and these correlations are insufficient to suggest cross-resistance. Benflumetol may be an important alternative drug for the treatment of chloroquine-resistant malaria.

* Corresponding author. Mailing address: IMTSSA, Unité de Parasitologie, Blvd. Charles Livon, Parc le Pharo, BP 46, 13998 Marseille Armees, France. Phone: 33 4 91 15 01 50. Fax: 33 4 91 59 44 77. E-mail: imtssa{at}gulliver.fr.

Antimicrobial Agents and Chemotherapy, February 1999, p. 418-420, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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