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Antimicrobial Agents and Chemotherapy, March 1999, p. 697-698, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Fosfomycin Alters Lipopolysaccharide-Induced Inflammatory Cytokine Production in Mice

Tetsuya Matsumoto,1,* Kazuhiro Tateda,1 Shuichi Miyazaki,1 Nobuhiko Furuya,1 Akira Ohno,1 Yoshikazu Ishii,1 Yoichi Hirakata,2 and Keizo Yamaguchi1

Department of Microbiology, Toho University School of Medicine, Omori-Nishi, Ota-ku, Tokyo,1 and Department of Laboratory Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki,2 Japan

Received 22 June 1998/Returned for modification 25 October 1998/Accepted 26 December 1998

To determine the mechanisms of immunomodulating action of fosfomycin (FOF), we examined its effect on the production of inflammatory cytokines in mice injected with lipopolysaccharide (LPS). Treatment with FOF significantly lowered the peak serum levels of tumor necrosis factor alpha and interleukin-1beta , indicating that FOF alters inflammatory cytokine production after LPS stimulation.

* Corresponding author. Mailing address: Department of Microbiology, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan. Phone: 81 (3) 3762-4151, ext. 2396. Fax: 81 (3) 5493-5415. E-mail: tetsu{at}med.toho-u.ac.jp.

Antimicrobial Agents and Chemotherapy, March 1999, p. 697-698, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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