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Antimicrobial Agents and Chemotherapy, March 1999, p. 714-716, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Lactic Acid Polymers as Biodegradable Carriers of Fluoroquinolones: An In Vitro Study

Kyriaki Kanellakopoulou,1 Maria Kolia,2 Antonios Anastassiadis,3 Themistoklis Korakis,3 Evangelos J. Giamarellos-Bourboulis,2 Andreas Andreopoulos,4 Eleftherios Dounis,3 and Helen Giamarellou1,*

Fourth Department of Internal Medicine, Athens Medical School, Sismanoglion General Hospital,1 First Department of Propedeutic Medicine, Athens Medical School,2 and Department of Orthopaedics,3 Laiko General Hospital, and Department of Chemical Engineering, Athens Polytechnique School,4 Athens, Greece

Received 5 May 1998/Returned for modification 3 November 1998/Accepted 26 December 1998

A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described. Duration and peak of release were found to depend on the molecular weight of the polymer. Its characteristics make it promising for treating chronic bone infections.

* Corresponding author. Mailing address: Fourth Department of Internal Medicine, Sismanoglion General Hospital, Athens 151 26, Greece. Phone: (301) 80 39 542. Fax: (301) 80 39 543.

Antimicrobial Agents and Chemotherapy, March 1999, p. 714-716, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.