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Antimicrobial Agents and Chemotherapy, April 1999, p. 950-953, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Protection by Short-Chain Fatty Acids against 1-beta -D-Arabinofuranosylcytosine-Induced Intestinal Lesions in Germfree Micedagger

Mariana Gontijo Ramos,1 Eduardo Alves Bambirra,2 Jacques Robert Nicoli,3 Denise Carmona Cara,4 Enio Cardillo Vieira,1 and Jacqueline Alvarez-Leite1,*

Departamento de Bioquímica e Imunologia, ICB-UFMG,1 Departamento de Anatomia Patológica, Faculdade de Medicina, UFMG,2 Departamento de Microbiologia3 and Departamento de Patologia,4 ICB-UFM, 30.161-970 Belo Horizonte, MG, Brazil

Received 12 June 1998/Returned for modification 14 October 1998/Accepted 24 January 1999

In germfree mice, the administration of short-chain fatty acids (SCFA) protected the intestinal mucosa from damage produced by 1-beta -D-arabinofuranosylcytosine (Ara-C). Animals receiving SCFA and Ara-C had intestinal morphologies closer to normal than the control animals, which had severe intestinal lesions. We concluded that orally administrated SCFA reduce intestinal lesions, improving the mucosa pattern of the small intestine and colon.

* Corresponding author. Mailing address: Departamento de Bioquímica e Imunologia, ICB-UFMG, Caixa Postal 486, 30.161-970 Belo Horizonte, MG, Brazil. Phone: 5531 4992652. Fax: 5531 4415963. E-mail: alvarez{at}mono.icb.ufmg.br.

dagger This work was performed at the Laboratório de Gnotobiologia e Nutrição, Departamento de Bioquímica e Imunologia, ICB-UFMG, Belo Horizonte, MG, Brazil.

Antimicrobial Agents and Chemotherapy, April 1999, p. 950-953, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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Copyright © 1999 by the American Society for Microbiology. All rights reserved.