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Antimicrobial Agents and Chemotherapy, April 1999, p. 978-980, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Effect of 3-Hydroxyphthaloyl-beta -Lactoglobulin on Vaginal Transmission of Simian Immunodeficiency Virus in Rhesus Monkeys

Michael S. Wyand,1,* Kelledy H. Manson,1 Christopher J. Miller,2 and A. Robert Neurath3

Primedica Corporation, Worcester, Massachusetts1; University of California, Davis, Davis, California2; and The Lindsey F. Kimball Research Institute of The New York Blood Center, New York, New York3

Received 15 June 1998/Returned for modification 18 September 1998/Accepted 19 January 1999

Heterosexual transmission of human immunodeficiency virus type 1 (HIV-1) is the major cause of the ongoing AIDS epidemic. Application of chemical barrier methods is expected to contribute to the worldwide control of this epidemic. Bovine beta -lactoglobulin modified by 3-hydroxyphthalic anhydride (3-hydroxyphthaloyl-beta -lactoglobulin [3HP-beta -LG]) was shown to inhibit HIV-1, HIV-2, simian immunodeficiency virus (SIV), herpes simplex virus type 1 and 2, and Chlamydia trachomatis infection in vitro. Here, we show that 3HP-beta -LG not formulated into any vehicle protected three of six rhesus monkeys against vaginal infection by SIV. Incorporation of the compound into an appropriate vehicle is expected to increase the degree of protection. 3HP-beta -LG may be effective as a vaginal inhibitor of HIV-1 infection in humans.

* Corresponding author. Mailing address: Primedica Corporation, 57 Union St., Worcester, MA 01608. Phone: (508) 890-0100. Fax: (508) 753-1834. E-mail: michael.wyand{at}primedica.com.

Antimicrobial Agents and Chemotherapy, April 1999, p. 978-980, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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