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Antimicrobial Agents and Chemotherapy, April 1999, p. 990-992, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Growth in the Presence of Salicylate Increases Fluoroquinolone Resistance in Staphylococcus aureus

John E. Gustafson,* Pierre V. Candelaria, Scott A. Fisher, Jodie P. Goodridge, Tanya M. Lichocik, Tracy M. McWilliams, Christopher T. D. Price, Frances G. O'Brien, and Warren B. Grubb

Microbiology Group, School of Biomedical Sciences, Curtin University of Technology, Perth 6845, Western Australia, Australia

Received 28 April 1998/Returned for modification 16 July 1998/Accepted 22 September 1998

Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible and -resistant Staphylococcus aureus. Salicylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salicylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin.

* Corresponding author. Mailing address: School of Biomedical Sciences, Curtin University of Technology, GPO Box U 1987, Perth 6845 Western Australia, Australia. Phone: 61 8 9266 7434. Fax: 61 8 9266 2342. E-mail: tgustafs{at}alpha2.curtin.edu.au.

Antimicrobial Agents and Chemotherapy, April 1999, p. 990-992, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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