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Antimicrobial Agents and Chemotherapy, May 1999, p. 1062-1066, Vol. 43, No. 5
Faculté de Médecine,
Received 7 October 1998/Returned for modification 15 January
1999/Accepted 11 February 1999
The relative frequency of 10 determinants of resistance to
macrolides, lincosamides, and streptogramins was investigated by PCR in
a series of 294 macrolide-, lincosamide-, and/or
streptogramin-resistant clinical isolates of Staphylococcus
aureus and coagulase-negative staphylococci isolated in 1995 from
32 French hospitals. Resistance was mainly due to the presence of
ermA or ermC genes, which were detected in 259 strains (88%), in particular those resistant to methicillin (78% of
the strains). Macrolide resistance due to msrA was more
prevalent in coagulase-negative staphylococci (14.6%) than in
S. aureus (2.1%). Genes related to
linA/linA' and conferring resistance to lincomycin were
detected in one strain of S. aureus and seven strains
of coagulase-negative staphylococci. Resistance to pristinamycin and
quinupristin-dalfopristin was phenotypically detected in 10 strains of
S. aureus and in three strains of coagulase-negative staphylococci; it was always associated with resistance to type A
streptogramins encoded by vat or vatB genes and
occurred in association with erm genes. The vga
gene conferring decreased susceptibility to type A streptogramins was
present alone in three strains of coagulase-negative staphylococci and
in combination with erm genes in 10 strains of
coagulase-negative staphylococci. A combination of
vga-vgb-vat and ermA genes was found in a
single strain of S. epidermidis.
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Distribution of Genes Encoding Resistance to Macrolides,
Lincosamides, and Streptogramins among Staphylococci
*
Corresponding author. Mailing address:
Faculté de Médecine, Laboratoire de
Bactériologie, Centre National de Référence des
Toxémies à Staphylocoques, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France. Phone: 33-478-77-86-57. Fax:
33-478-77-86-58. E-mail: geralina{at}univ-lyon1.fr.
Antimicrobial Agents and Chemotherapy, May 1999, p. 1062-1066, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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