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Antimicrobial Agents and Chemotherapy, May 1999, p. 1267-1269, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

N-Acylated and D Enantiomer Derivatives of a Nonamer Core Peptide of Lactoferricin B Showing Improved Antimicrobial Activity

Hiroyuki Wakabayashi,1,* Hiroshi Matsumoto,2 Koichi Hashimoto,2 Susumu Teraguchi,1 Mitsunori Takase,1 and Hirotoshi Hayasawa1

Nutritional Science Laboratory1 and Biochemical Research Laboratory,2 Morinaga Milk Industry Co., Ltd., Zama, Kanagawa 228-8583, Japan

Received 2 September 1998/Returned for modification 8 January 1999/Accepted 7 March 1999

N-acylated or D enantiomer peptide derivatives based on the sequence RRWQWRMKK in lactoferricin B demonstrated antimicrobial activities greater than those of lactoferricin B against bacteria and fungi. The most potent peptide, conjugated with an 11-carbon-chain acyl group, showed two to eight times lower MIC than lactoferricin B.

* Corresponding author. Mailing address: Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama, Kanagawa 228-8583, Japan. Phone: 81-462-52-3045. Fax: 81-462-52-3049. E-mail: Hiroyuki_Wa{at}msn.com.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1267-1269, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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