Previous Article | Next Article ![]()
Antimicrobial Agents and Chemotherapy, May 1999, p. 1274-1276, Vol. 43, No. 5
Department of Microbiology and Immunology,
University of British Columbia, Vancouver, British Columbia, Canada
V6T 1Z3
Received 8 October 1998/Returned for modification 14 January
1999/Accepted 11 February 1999
Both linear and cyclic derivatives of the cyclic 12-amino-acid
antimicrobial peptide bactenecin were designed based on optimization of
amphipathicity and charge location. In general, increasing the number
of positive charges at the N and C termini and adding an extra
tryptophan residue in the loop not only increased the activities
against both gram-positive and gram-negative bacteria but also
broadened the antimicrobial spectrum.
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Improved Derivatives of Bactenecin, a Cyclic
Dodecameric Antimicrobial Cationic Peptide
*
Corresponding author. Mailing address: Department of
Microbiology and Immunology, University of British Columbia, 300-6174 University Blvd., Vancouver, B.C. V6T 1Z3, Canada. Phone: (604) 822-2682. Fax: (604) 822-6041. E-mail: bob{at}cmdr.ubc.ca.
This article has been cited by other articles:
Copyright © 2010 by the American Society for Microbiology. For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»