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Antimicrobial Agents and Chemotherapy, May 1999, p. 1281-1284, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

An SHV-Derived Extended-Spectrum beta -Lactamase in Pseudomonas aeruginosa

Thierry Naas,1,2 Laurence Philippon,1 Laurent Poirel,1 Esthel Ronco,3 and Patrice Nordmann1,*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre,1 Service de Bactériologie-Virologie, Hôpital Antoine Béclère, Faculté de Médecine Paris-Sud, 92141 Clamart Cedex,2 and Service de Microbiologie, Hôpital Raymond Poincaré, Faculté de Médecine Paris-Ouest, 92380 Garches,3 Assistance Publique/Hôpitaux de Paris, France

Received 12 October 1998/Returned for modification 25 January 1999/Accepted 26 February 1999

A clinical isolate of Pseudomonas aeruginosa RP-1 produced the extended-spectrum beta -lactamase (ESBL) SHV-2a. Its gene was expressed from a composite promoter made of the -35 region derived from the left inverted repeat of IS26 and the -10 region from the blaSHV-2a promoter itself. The DNA sequences immediately surrounding blaSHV-2a were homologous to plasmid pMPA2a from Klebsiella pneumoniae KpZU-3, while further away and 3' to the blaSHV-2a gene, a sequence corresponding to the left end of Tn1721 was detected, thus indicating a likely enterobacterial origin of this ESBL gene.

* Corresponding author. Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, Le Kremlin-Bicêtre 94275, France. Phone: 33 1 45 21 36 32. Fax: 33 1 45 21 63 40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1281-1284, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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