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Antimicrobial Agents and Chemotherapy, May 1999, p. 1289-1290, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Correlation between In Vitro Susceptibility Determined by E Test and Response to Therapy with Amphotericin B: Results from a Multicenter Prospective Study of Candidemia

Cornelius J. Clancy and M. Hong Nguyen*

Department of Medicine, Division of Infectious Diseases, University of Florida College of Medicine, and VA Medical Center, Gainesville, Florida

Received 8 July 1998/Returned for modification 8 October 1998/Accepted 11 March 1999

Ninety-nine Candida bloodstream isolates underwent testing for susceptibility to amphotericin B by the E test, and the results were correlated with patients' responses to amphotericin B. The MICs for isolates that were associated with therapeutic failure were significantly higher than the MICs for those associated with therapeutic success. A MIC of >= 0.38 µg/ml identified isolates likely to be associated with therapeutic failure.

* Corresponding author. Mailing address: University of Florida College of Medicine, Department of Medicine, Division of Infectious Diseases, P.O. Box 100277, JHMHC, Gainesville, FL 32610. Phone: (352) 392-4058. Fax: (352) 392-6481. E-mail: nguyemt{at}medicine.ufl.edu.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1289-1290, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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