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Antimicrobial Agents and Chemotherapy, May 1999, p. 1307-1309, Vol. 43, No. 5
Department of Clinical
Pharmacology,1 Department of Internal
Medicine I,
Received 11 August 1998/Returned for modification 3 January
1999/Accepted 3 March 1999
Interstitial ciprofloxacin concentrations in soft tissues were
measured by microdialysis following intravenous administration of 200 mg to each of eight healthy volunteers. Interstitial ciprofloxacin concentrations were significantly lower than corresponding total serum
drug concentrations; the interstitium-to-serum concentration ratios
ranged from 0.55 to 0.73. An in vitro simulation based on interstitial
pharmacokinetics showed a substantially lower antimicrobial activity
than did the simulation based on serum pharmacokinetics. Thus,
ciprofloxacin concentrations at the site of effect may be subinhibitory
although effective concentrations are attained in serum.
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Distribution and Antimicrobial Activity of
Ciprofloxacin in Human Soft Tissues
*
Corresponding author. Mailing address: Department of
Clinical Pharmacology, Division of Clinical Pharmacokinetics,
University of Vienna Medical School, Allgemeines Krankenhaus,
Währinger Gürtel 18-20, A-1090 Vienna, Austria. Phone:
43-1-40400-2981. Fax: 43-1-40400-2998. E-mail:
markus.mueller{at}univie.ac.at.
Antimicrobial Agents and Chemotherapy, May 1999, p. 1307-1309, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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