This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brunner, M.
Right arrow Articles by Müller, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brunner, M.
Right arrow Articles by Müller, M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 1999, p. 1307-1309, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues

Martin Brunner,1 Ursula Hollenstein,2 Simon Delacher,1 Dorothea Jäger,1 Rainer Schmid,3 Edith Lackner,1 Apostoulos Georgopoulos,2 Hans Georg Eichler,1 and Markus Müller1,*

Department of Clinical Pharmacology,1 Department of Internal Medicine I, Division of Infectious Diseases and Chemotherapy,2 and Department of Clinical and Laboratory Investigation,3 University of Vienna Medical School, Vienna, Austria

Received 11 August 1998/Returned for modification 3 January 1999/Accepted 3 March 1999

Interstitial ciprofloxacin concentrations in soft tissues were measured by microdialysis following intravenous administration of 200 mg to each of eight healthy volunteers. Interstitial ciprofloxacin concentrations were significantly lower than corresponding total serum drug concentrations; the interstitium-to-serum concentration ratios ranged from 0.55 to 0.73. An in vitro simulation based on interstitial pharmacokinetics showed a substantially lower antimicrobial activity than did the simulation based on serum pharmacokinetics. Thus, ciprofloxacin concentrations at the site of effect may be subinhibitory although effective concentrations are attained in serum.


* Corresponding author. Mailing address: Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, Allgemeines Krankenhaus, Währinger Gürtel 18-20, A-1090 Vienna, Austria. Phone: 43-1-40400-2981. Fax: 43-1-40400-2998. E-mail: markus.mueller{at}univie.ac.at.


Antimicrobial Agents and Chemotherapy, May 1999, p. 1307-1309, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.



This article has been cited by other articles:

  • Schmidt, S., Banks, R., Kumar, V., Rand, K. H., Derendorf, H. (2008). Clinical Microdialysis in Skin and Soft Tissues: An Update. J Clin Pharmacol 48: 351-364 [Abstract] [Full Text]  
  • Burkhardt, O., Brunner, M., Schmidt, S., Grant, M., Tang, Y., Derendorf, H. (2006). Penetration of ertapenem into skeletal muscle and subcutaneous adipose tissue in healthy volunteers measured by in vivo microdialysis. J Antimicrob Chemother 58: 632-636 [Abstract] [Full Text]  
  • Langer, O., Karch, R., Muller, U., Dobrozemsky, G., Abrahim, A., Zeitlinger, M., Lackner, E., Joukhadar, C., Dudczak, R., Kletter, K., Muller, M., Brunner, M. (2005). Combined PET and Microdialysis for In Vivo Assessment of Intracellular Drug Pharmacokinetics in Humans. JNM 46: 1835-1841 [Abstract] [Full Text]  
  • Joukhadar, C., Dehghanyar, P., Traunmuller, F., Sauermann, R., Mayer-Helm, B., Georgopoulos, A., Muller, M. (2005). Increase of Microcirculatory Blood Flow Enhances Penetration of Ciprofloxacin into Soft Tissue. Antimicrob. Agents Chemother. 49: 4149-4153 [Abstract] [Full Text]  
  • Zeitlinger, M. A., Erovic, B. M., Sauermann, R., Georgopoulos, A., Muller, M., Joukhadar, C. (2005). Plasma concentrations might lead to overestimation of target site activity of piperacillin in patients with sepsis. J Antimicrob Chemother 56: 703-708 [Abstract] [Full Text]  
  • Schuck, E. L., Grant, M., Derendorf, H. (2005). Effect of Simulated Microgravity on the Disposition and Tissue Penetration of Ciprofloxacin in Healthy Volunteers. J Clin Pharmacol 45: 822-831 [Abstract] [Full Text]  
  • Liu, P., Muller, M., Grant, M., Obermann, B., Derendorf, H. (2005). Tissue Penetration of Cefpodoxime and Cefixime in Healthy Subjects. J Clin Pharmacol 45: 564-569 [Abstract] [Full Text]  
  • Islinger, F., Bouw, R., Stahl, M., Lackner, E., Zeleny, P., Brunner, M., Muller, M., Eichler, H. G., Joukhadar, C. (2004). Concentrations of Gemifloxacin at the Target Site in Healthy Volunteers after a Single Oral Dose. Antimicrob. Agents Chemother. 48: 4246-4249 [Abstract] [Full Text]  
  • Brunner, M., Langer, O., Dobrozemsky, G., Muller, U., Zeitlinger, M., Mitterhauser, M., Wadsak, W., Dudczak, R., Kletter, K., Muller, M. (2004). [18F]Ciprofloxacin, a New Positron Emission Tomography Tracer for Noninvasive Assessment of the Tissue Distribution and Pharmacokinetics of Ciprofloxacin in Humans. Antimicrob. Agents Chemother. 48: 3850-3857 [Abstract] [Full Text]  
  • Muller, M., dela Pena, A., Derendorf, H. (2004). Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue. Antimicrob. Agents Chemother. 48: 1441-1453 [Full Text]  
  • Brunner, M., Stass, H., Moller, J.-G., Schrolnberger, C., Erovic, B., Hollenstein, U., Zeitlinger, M., Eichler, H. G., Muller, M. (2002). Target Site Concentrations of Ciprofloxacin after Single Intravenous and Oral Doses. Antimicrob. Agents Chemother. 46: 3724-3730 [Abstract] [Full Text]  
  • Leone, M., Sampol-Manos, E., Santelli, D., Grabowski, S., Alliez, B., Durand, A., Lacarelle, B., Martin, C. (2002). Brain tissue penetration of ciprofloxacin following a single intravenous dose. J Antimicrob Chemother 50: 607-609 [Abstract] [Full Text]  
  • Ba, B. B., Bernard, A., Iliadis, A., Quentin, C., Ducint, D., Etienne, R., Fourtillan, M., Maachi-Guillot, I., Saux, M.-C. (2001). New approach for accurate simulation of human pharmacokinetics in an in vitro pharmacodynamic model: application to ciprofloxacin. J Antimicrob Chemother 47: 223-227 [Abstract] [Full Text]  
  • Delacher, S., Derendorf, H., Hollenstein, U., Brunner, M., Joukhadar, C., Hofmann, S., Georgopoulos, A., Eichler, H. G., Muller, M. (2000). A combined in vivo pharmacokinetic-in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans. J Antimicrob Chemother 46: 733-739 [Abstract] [Full Text]  
  • Frossard, M., Joukhadar, C., Erovic, B. M., Dittrich, P., Mrass, P. E., Van Houte, M., Burgmann, H., Georgopoulos, A., Müller, M. (2000). Distribution and Antimicrobial Activity of Fosfomycin in the Interstitial Fluid of Human Soft Tissues. Antimicrob. Agents Chemother. 44: 2728-2732 [Abstract] [Full Text]  
  • Müller, M., Brunner, M., Hollenstein, U., Joukhadar, C., Schmid, R., Minar, E., Ehringer, H., Eichler, H. G. (1999). Penetration of Ciprofloxacin into the Interstitial Space of Inflamed Foot Lesions in Non-Insulin-Dependent Diabetes Mellitus Patients. Antimicrob. Agents Chemother. 43: 2056-2058 [Abstract] [Full Text]