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Antimicrobial Agents and Chemotherapy, May 1999, p. 1307-1309, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues

Martin Brunner,1 Ursula Hollenstein,2 Simon Delacher,1 Dorothea Jäger,1 Rainer Schmid,3 Edith Lackner,1 Apostoulos Georgopoulos,2 Hans Georg Eichler,1 and Markus Müller1,*

Department of Clinical Pharmacology,1 Department of Internal Medicine I, Division of Infectious Diseases and Chemotherapy,2 and Department of Clinical and Laboratory Investigation,3 University of Vienna Medical School, Vienna, Austria

Received 11 August 1998/Returned for modification 3 January 1999/Accepted 3 March 1999

Interstitial ciprofloxacin concentrations in soft tissues were measured by microdialysis following intravenous administration of 200 mg to each of eight healthy volunteers. Interstitial ciprofloxacin concentrations were significantly lower than corresponding total serum drug concentrations; the interstitium-to-serum concentration ratios ranged from 0.55 to 0.73. An in vitro simulation based on interstitial pharmacokinetics showed a substantially lower antimicrobial activity than did the simulation based on serum pharmacokinetics. Thus, ciprofloxacin concentrations at the site of effect may be subinhibitory although effective concentrations are attained in serum.

* Corresponding author. Mailing address: Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, Allgemeines Krankenhaus, Währinger Gürtel 18-20, A-1090 Vienna, Austria. Phone: 43-1-40400-2981. Fax: 43-1-40400-2998. E-mail: markus.mueller{at}univie.ac.at.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1307-1309, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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