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Antimicrobial Agents and Chemotherapy, May 1999, p. 1310-1313, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Emergence of Fluoroquinolone Resistance among Multiply Resistant Strains of Streptococcus pneumoniae in Hong Kong

Pak-Leung Ho,1,* Tak-Lun Que,2 Dominic Ngai-Chong Tsang,3 Tak-Keung Ng,4 Kin-Hung Chow,1 and Wing-Hon Seto5

Department of Microbiology, Division of Infectious Diseases, University of Hong Kong,1 Department of Microbiology, Queen Mary Hospital,5 Department of Pathology, Tuen Mun Hospital,2 Department of Microbiology, Queen Elizabeth Hospital,3 and Department of Microbiology, Princess Margaret Hospital,4 Hong Kong

Received 8 December 1998/Returned for modification 29 January 1999/Accepted 3 March 1999

The MICs of 17 antimicrobial agents for 181 Streptococcus pneumoniae strains were determined by the E-test. Overall, 69.1% were penicillin resistant (MIC > 0.06 µg/ml). Resistance to ciprofloxacin (MIC > 2 µg/ml), levofloxacin (MIC > 2 µg/ml), or trovafloxacin (MIC > 1 µg/ml) was found in 12.1, 5.5, or 2.2% of the strains, respectively. These high rates of resistance raise concerns for the future.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong. Phone: 852-2855 4897. Fax: 852-2855 1241. E-mail: plho{at}hkucc.hku.hk.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1310-1313, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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  • Richardson, D. C., Bast, D., McGeer, A., Low, D. E. (2001). Evaluation of Susceptibility Testing To Detect Fluoroquinolone Resistance Mechanisms in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 45: 1911-1914 [Abstract] [Full Text]  
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  • Cubbon, M. D., Masterton, R. G. (2000). New quinolones--a fresh answer to the pneumococcus. J Antimicrob Chemother 46: 869-872 [Full Text]  
  • Wright, D. H., Brown, G. H., Peterson, M. L., Rotschafer, J. C. (2000). Application of fluoroquinolone pharmacodynamics. J Antimicrob Chemother 46: 669-683 [Abstract] [Full Text]  
  • Kumarasinghe, G., Chow, C., Tambyah, P. A. (2000). The emergence of resistance to levofloxacin before clinical use in a university hospital in Singapore. J Antimicrob Chemother 46: 862-863 [Full Text]  
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