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Antimicrobial Agents and Chemotherapy, May 1999, p. 1314-1316, Vol. 43, No. 5
0066-4804/99/$04.00+0

Sensitivity of Spermidine-Deficient Saccharomyces cerevisiae to Paromomycin

David Balasundaram, Celia White Tabor, and Herbert Tabor*

National Institutes of Health, Bethesda, Maryland 20892-0830

Received 14 August 1998/Returned for modification 27 January 1999/Accepted 5 March 1999

Spermidine-deficient Saccharomyces cerevisiae cells are much more sensitive to paromomycin than nondeficient cells, resulting in cessation of growth and cell death.

* Corresponding author. Mailing address: NIH-NIDDK, Building 8, Room 225, Bethesda, MD 20892-0830. Phone: (301) 496-2562. Fax: (301) 402-0240. E-mail: tabor{at}helix.nih.gov.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1314-1316, Vol. 43, No. 5
0066-4804/99/$04.00+0


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