This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Auclair, B.
Right arrow Articles by Ducharme, M. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Auclair, B.
Right arrow Articles by Ducharme, M. P.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 1999, p. 1465-1468, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Piperacillin and Tazobactam Exhibit Linear Pharmacokinetics after Multiple Standard Clinical Doses

Barbara Auclairdagger and Murray P. Ducharme*

Faculté de Pharmacie, Université de Montréal, Montréal, Canada

Received 14 August 1998/Returned for modification 3 January 1999/Accepted 21 March 1999

A population pharmacokinetic (PK) analysis was conducted to determine if piperacillin and tazobactam exhibited linear or nonlinear PKs and if incremental changes in the daily dosage of piperacillin affected tazobactam PKs. Four dosage groups were evaluated after multiple dosing regimens. Concentrations of drug in plasma and amounts in urine were best fitted by using a linear two-compartment PK model. No significant difference between dosing groups was seen for any piperacillin or tazobactam PK parameters. Both drugs exhibited linear PKs when given at usual clinical doses. Tazobactam PKs did not appear to be affected by the different dosing regimens of piperacillin.

* Corresponding author. Present address: Phoenix International Life Sciences, 2350 Cohen St., Saint-Laurent, Québec, Canada, H4R 2N6. Phone: (514) 333-0042, ext. 4520. Fax: (514) 333-7666. E-mail: ducharmu{at}earthlink.net.

dagger Present address: National Jewish Medical and Research Center, Denver, Colo.

Antimicrobial Agents and Chemotherapy, June 1999, p. 1465-1468, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Li, C., Kuti, J. L., Nightingale, C. H., Mansfield, D. L., Dana, A., Nicolau, D. P. (2005). Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection. J Antimicrob Chemother 56: 388-395 [Abstract] [Full Text]  
  • Lodise, T. P. Jr., Lomaestro, B., Rodvold, K. A., Danziger, L. H., Drusano, G. L. (2004). Pharmacodynamic Profiling of Piperacillin in the Presence of Tazobactam in Patients through the Use of Population Pharmacokinetic Models and Monte Carlo Simulation. Antimicrob. Agents Chemother. 48: 4718-4724 [Abstract] [Full Text]  
  • Vinks, A. A., den Hollander, J. G., Overbeek, S. E., Jelliffe, R. W., Mouton, J. W. (2003). Population Pharmacokinetic Analysis of Nonlinear Behavior of Piperacillin during Intermittent or Continuous Infusion in Patients with Cystic Fibrosis. Antimicrob. Agents Chemother. 47: 541-547 [Abstract] [Full Text]  
  • Mueller, S. C., Majcher-Peszynska, J., Hickstein, H., Francke, A., Pertschy, A., Schulz, M., Mundkowski, R., Drewelow, B. (2002). Pharmacokinetics of Piperacillin-Tazobactam in Anuric Intensive Care Patients during Continuous Venovenous Hemodialysis. Antimicrob. Agents Chemother. 46: 1557-1560 [Abstract] [Full Text]  
  • Kim, M.-K., Xuan, D., Quintiliani, R., Nightingale, C. H., Nicolau, D. P. (2001). Pharmacokinetic and pharmacodynamic profile of high dose extended interval piperacillin-tazobactam. J Antimicrob Chemother 48: 259-267 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»