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Antimicrobial Agents and Chemotherapy, June 1999, p. 1497-1499, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Rifampin and Rifabutin Resistance Mechanism in Helicobacter pylori

Markus Heep,1,* Daniela Beck,1 Ekkehard Bayerdörffer,2 and Norbert Lehn1

Institut für Medizinische Mikrobiologie, Universitätsklinikum Regensburg, D-93053, Regensburg,1 and Department of Internal Medicine I, Universitätsklinikum Carl Gustav Carus, D-01307 Dresden,2 Germany

Received 23 November 1998/Returned for modification 19 February 1999/Accepted 25 March 1999

Eighty-one clinical isolates of Helicobacter pylori showed no resistance to rifampin (MIC range, 0.032 to 2 µg/ml; MIC at which 50% of isolates are inhibited [MIC50], 0.25 µg/ml). The MIC50 of rifabutin was 0.008 µg/ml (n = 16). All resistant laboratory mutants of H. pylori ATCC 43504 showed amino acid exchanges in codons 524 to 545 or codon 585 of the rpoB gene, corresponding to the gene sequences from Mycobacterium tuberculosis and Escherichia coli.

* Corresponding author. Mailing address: Institut für Medizinische Mikrobiologie, Uniklinik Regensburg, D-93053, Regensburg, Germany. Phone: 49 941 944-6414. Fax: 49 941 944-6402. E-mail: Markus.Heep{at}klinik.uni-regensburg.de.

Antimicrobial Agents and Chemotherapy, June 1999, p. 1497-1499, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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