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Antimicrobial Agents and Chemotherapy, June 1999, p. 1525-1527, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro Activities of Pyronaridine, Alone and in Combination with Other Antimalarial Drugs, against Plasmodium falciparum

Pascal Ringwald,* Else Carole Moukoko Eboumbou, Jean Bickii, and Leonardo K. Basco

Institut de Recherche pour le Développement-Laboratoire de Recherche sur le Paludisme, Laboratoire Associé Francophone 302, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon

Received 16 December 1998/Returned for modification 1 February 1999/Accepted 30 March 1999

The in vitro activities of pyronaridine, alone and in combination with established antimalarial drugs, were assessed by isotopic microtest. Pyronaridine was highly active against all Cameroonian isolates. A positive correlation was observed between the response to pyronaridine and that to chloroquine. Drug combination studies showed synergy between pyronaridine and primaquine, additive effects with 4-aminoquinolines, and weak antagonism with dihydroartemisinin, antifolates, or amino alcohols.

* Corresponding author. Mailing address: OCEAC, BP 288, Yaoundé, Cameroon. Phone: 237 23 22 32. Fax: 237 23 00 61. E-mail: oceac{at}camnet.cm.

Antimicrobial Agents and Chemotherapy, June 1999, p. 1525-1527, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • BASCO, L. K., RINGWALD, P. (2007). MOLECULAR EPIDEMIOLOGY OF MALARIA IN CAMEROON. XXIV. TRENDS OF IN VITRO ANTIMALARIAL DRUG RESPONSES IN YAOUNDE, CAMEROON. Am J Trop Med Hyg 76: 20-26 [Abstract] [Full Text]  
  • Auparakkitanon, S., Chapoomram, S., Kuaha, K., Chirachariyavej, T., Wilairat, P. (2006). Targeting of hematin by the antimalarial pyronaridine.. Antimicrob. Agents Chemother. 50: 2197-2200 [Abstract] [Full Text]  


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