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Antimicrobial Agents and Chemotherapy, July 1999, p. 1651-1656, Vol. 43, No. 7
Institute for Medical Microbiology, CH-3010
Bern, Switzerland,1 and Clinique des
Maladies Infectieuses2 and Clinique
de Pharmacologie Clinique,3 Hôpital
Pontchaillou, 35033 Rennes Cedex, France
Received 18 September 1998/Returned for modification 7 December
1998/Accepted 23 April 1999
The antibacterial activities of amoxicillin-gentamicin,
trovafloxacin, trimethoprim-sulfamethoxazole (TMP-SMX) and the
combination of trovafloxacin with TMP-SMX were compared in a model of
meningoencephalitis due to Listeria monocytogenes in infant
rats. At 22 h after intracisternal infection, the cerebrospinal
fluid was cultured to document meningitis, and the treatment was
started. Treatment was instituted for 48 h, and efficacy was
evaluated 24 h after administration of the last dose. All tested
treatment regimens exhibited significant activities in brain, liver,
and blood compared to infected rats receiving saline
(P < 0.001). In the brain, amoxicillin plus
gentamicin was more active than all of the other regimens, and
trovafloxacin was more active than TMP-SMX (bacterial titers of
4.1 ± 0.5 log10 CFU/ml for amoxicillin-gentamicin,
5.0 ± 0.4 log10 CFU/ml for trovafloxacin, and
5.8 ± 0.5 log10 CFU/ml for TMP-SMX;
P < 0.05). In liver, amoxicillin-gentamicin and
trovafloxacin were similarly active (2.8 ± 0.8 and 2.7 ± 0.8 log10 CFU/ml, respectively) but more active than
TMP-SMX (4.4 ± 0.6 log10 CFU/ml; P < 0.05). The combination of trovafloxacin with TMP-SMX did not alter
the antibacterial effect in the brain, but it did reduce the effect of
trovafloxacin in the liver. Amoxicillin-gentamicin was the most active
therapy in this study, but the activity of trovafloxacin suggests that further studies with this drug for the treatment of
Listeria infections may be warranted.
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Comparative Efficacies of Antibiotics in a Rat
Model of Meningoencephalitis Due to Listeria
monocytogenes
*
Corresponding author. Mailing address: Clinique des
Maladies Infectieuses, Hôpital Pontchaillou, 35033 Rennes
Cedex, France. Phone: 33-(0)2-99-28-42-87. Fax: 33-(0)2-99-28-24-52.
E-mail: christian.michelet{at}univ-rennes1.fr.
Antimicrobial Agents and Chemotherapy, July 1999, p. 1651-1656, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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