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Antimicrobial Agents and Chemotherapy, July 1999, p. 1754-1755, Vol. 43, No. 7
Department of Internal
Medicine1 and
Microbiology/Immunology,
Received 4 December 1998/Returned for modification 4 February
1999/Accepted 6 April 1999
The rabbit model of endocarditis was used to test the effectiveness
of vancomycin and two different lysostaphin dosing regimens for the
treatment of infections caused by a Staphylococcus aureus strain with reduced susceptibility to vancomycin
(glycopeptide-intermediate susceptible S. aureus [GISA]).
Vancomycin was ineffective, with no evidence of sterilization of aortic
valve vegetations. However, rates of sterilization of aortic valve
vegetations were significantly better for animals treated with either a
single dose of lysostaphin (43%) or lysostaphin given twice daily for
3 days (83%) than for animals treated with vancomycin. Rabbits given a
single dose of lysostaphin followed by a 3-day drug-free period had
mean reductions in aortic valve vegetation bacterial counts of 7.27 and
6.63 log10 CFU/g compared with those for untreated control
rabbits and the vancomycin-treated group, respectively. We conclude
that lysostaphin is an effective alternative for the treatment of
experimental aortic valve endocarditis caused by a clinical VISA strain.
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Lysostaphin Treatment of Experimental Aortic Valve
Endocarditis Caused by a Staphylococcus aureus Isolate with
Reduced Susceptibility to Vancomycin
*
Corresponding author. Mailing address: McGuire Veterans
Affairs Medical Center, 1201 Broad Rock Blvd., Section 111-C, Richmond, VA 23249. Phone: (804) 675-5018. Fax: (804) 675-5437. E-mail: Climo.Michael{at}Richmond.va.gov or
MWCLIMO{at}aol.com.
Antimicrobial Agents and Chemotherapy, July 1999, p. 1754-1755, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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