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Antimicrobial Agents and Chemotherapy, July 1999, p. 1764-1766, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

pncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis Isolates from Northwestern Russia

Harri J. Marttila,1,* Merja Marjamäki,1 Elena Vyshnevskaya,2 Boris I. Vyshnevskiy,2 Tatjana F. Otten,2 Alexandr V. Vasilyef,2 and Matti K. Viljanen1

Mycobacterial Reference Laboratory, National Public Health Institute, 20520 Turku, Finland,1 and Research Institution of Phthisiopulmonology, 193130 St. Petersburg, Russia2

Received 4 January 1999/Returned for modification 28 January 1999/Accepted 3 May 1999

Thirty-six pyrazinamide-resistant and eight pyrazinamide-susceptible Mycobacterium tuberculosis isolates from Russia were analyzed for their pncA mutations. Thirty-one (86.1%) of the resistant isolates had a mutation either in pncA or upstream of the gene. Twenty of the 23 different mutations found in this study had not been described earlier. pncA genotype correlated well with pyrazinamidase activity and BACTEC 460 susceptibility test results.

* Corresponding author. Mailing address: National Public Health Institute Department in Turku, Kiinamyllynkatu 13, 20520 Turku, Finland. Phone: 358-2-2519255. Fax: 358-2-2519254. E-mail: harmar{at}utu.fi.

Antimicrobial Agents and Chemotherapy, July 1999, p. 1764-1766, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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