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Antimicrobial Agents and Chemotherapy, July 1999, p. 1776-1778, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Improvement of In Vitro and In Vivo Antileishmanial Activities of 2',6'-Dihydroxy-4'-Methoxychalcone by Entrapment in Poly(D,L-Lactide) Nanoparticles

Eduardo Caio Torres-Santos,1 José M. Rodrigues Jr.,2 Davyson L. Moreira,3 Maria Auxiliadora C. Kaplan,3 and Bartira Rossi-Bergmann1,*

Instituto de Biofísica Carlos Chagas Filho1 and Núcleo de Pesquisas de Produtos Naturais,3 Universidade Federal do Rio de Janeiro, Rio de Janeiro, and Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte,2 Brazil

Received 5 October 1998/Returned for modification 12 November 1998/Accepted 7 May 1999

The inhibition of intracellular Leishmania amazonensis growth by 2',6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions.

* Corresponding author. Mailing address: Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21.949-900 Rio de Janeiro-RJ, Brazil. Phone: 55 (21) 260.6963. Fax: 55 (21) 280.8193. E-mail: bbergman{at}ibccf.biof.ufrj.br.

Antimicrobial Agents and Chemotherapy, July 1999, p. 1776-1778, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Torres-Santos, E. C., Sampaio-Santos, M. I., Buckner, F. S., Yokoyama, K., Gelb, M., Urbina, J. A., Rossi-Bergmann, B. (2009). Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone. J Antimicrob Chemother 63: 469-472 [Abstract] [Full Text]  


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