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Antimicrobial Agents and Chemotherapy, July 1999, p. 1788-1791, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro and In Vivo Activities of Tea Catechins against Helicobacter pylori

Katsuhiro Mabe,1,* Masami Yamada,2 Itaro Oguni,3 and Tsuneo Takahashi1

Second Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata City, Yamagata 990-9585,1 Gastrointestinal Division, Hamamatsu Medical Center, Hamamatsu City, Shizuoka 432-8002,2 and Department of Food and Nutritional Sciences, University of Shizuoka Hamamatsu College, 3-2-3 Nunohashi, Hamamatsu City, Shizuoka 432-8012,3 Japan

Received 21 September 1998/Returned for modification 13 January 1999/Accepted 19 April 1999

The catechin epigallocatechin gallate showed the strongest activity of the six tea catechins tested against Helicobacter pylori (MIC for 50% of the strains tested, 8 µg/ml). It had bactericidal activity at pH 7 but not at pH <= 5.0. In infected Mongolian gerbils, H. pylori was eradicated in 10 to 36% of the catechin-treated animals, with significant decreases in mucosal hemorrhage and erosion. Tea catechins, therefore, may have therapeutic effects on H. pylori infection.

* Corresponding author. Mailing address: Second Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata City, Yamagata 990-9585, Japan. Phone: 81-23-628-5309. Fax: 81-23-628-5311. E-mail: kmabe{at}med.id.yamagata-u.ac.jp.

Antimicrobial Agents and Chemotherapy, July 1999, p. 1788-1791, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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