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Antimicrobial Agents and Chemotherapy, July 1999, p. 1808-1810, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro Susceptibilities of Chlamydia pneumoniae Isolates from German Patients and Synergistic Activity of Antibiotic Combinations

Heike M. Freidank,* Philipp Losch, Heike Vögele, and Margit Wiedmann-Al-Ahmad

Department of Bacteriology, Institute for Medical Microbiology and Hygiene, University of Freiburg, D-79104 Freiburg, Germany

Received 23 November 1998/Returned for modification 8 March 1999/Accepted 10 May 1999

The susceptibilities of six Chlamydia pneumoniae type strains and of six German patient isolates to erythromycin, azithromycin, roxithromycin, clarithromycin, doxycycline, ofloxacin, and rifampin were investigated. MICs and minimal chlamydicidal concentrations were all within the ranges reported previously. Combinations of azithromycin with either ofloxacin, doxycycline, or rifampin, as well as combinations of three antibiotics (rifampin, azithromycin, and ofloxacin or doxycycline), showed synergistic activity against C. pneumoniae.

* Corresponding author. Mailing address: Department of Bacteriology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Hermann-Herder-Str. 11, D-79104 Freiburg, Germany. Phone: 049-761 203 6540. Fax: 049-761 203 6562. E-mail: freidank{at}sun11.ukl.uni-freiburg.de.

Antimicrobial Agents and Chemotherapy, July 1999, p. 1808-1810, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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