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Antimicrobial Agents and Chemotherapy, August 1999, p. 2038-2042, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Effects of the Human Immunodeficiency Virus (HIV) Proteinase
Inhibitors Saquinavir and Indinavir on In Vitro Activities of
Secreted Aspartyl Proteinases of Candida albicans
Isolates from HIV-Infected Patients
Hans C.
Korting,1
Martin
Schaller,1,*
Gabriele
Eder,1
Gerald
Hamm,2
Ursula
Böhmer,1 and
Bernhard
Hube3
Department of
Dermatology1 and Department of
Parodontology,2
Ludwig-Maximilians-University, Munich, and Institute for
General Botany, Applied Molecular Biology III, University of
Hamburg, Hamburg,3 Germany
Received 16 November 1998/Returned for modification 20 January
1999/Accepted 7 May 1999
The effects of therapeutically relevant concentrations of the human
immunodeficiency virus (HIV) proteinase inhibitors saquinavir and
indinavir on the in vitro proteinase activity of Candida
albicans were investigated with isolates from HIV-infected and
uninfected patients with oral candidiasis. After exposure to the HIV
proteinase inhibitors, proteinase activity was significantly reduced in
a dose-dependent manner. These inhibitory effects, which were similar to that of pepstatin A, and the reduced virulence phenotype in experimental candidiasis after application of saquinavir indicate the
usefulness of these HIV proteinase inhibitors as potential anticandidal agents.
*
Corresponding author. Mailing address: Dermatologische
Klinik und Poliklinik der Ludwig-Maximilians-Universität
München, Frauenlobstr. 9-11, D-80337 München, Germany.
Phone: 49 89 5160 6151. Fax: 49 89 5160 6007.
Antimicrobial Agents and Chemotherapy, August 1999, p. 2038-2042, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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