This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Müller, M.
Right arrow Articles by Eichler, H. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Müller, M.
Right arrow Articles by Eichler, H. G.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 1999, p. 2056-2058, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Penetration of Ciprofloxacin into the Interstitial Space of Inflamed Foot Lesions in Non-Insulin-Dependent Diabetes Mellitus Patients

Markus Müller,1,* Martin Brunner,1 Ursula Hollenstein,2 Christian Joukhadar,1 Rainer Schmid,3 Erich Minar,4 Herbert Ehringer,4 and Hans Georg Eichler1

Departments of Clinical Pharmacology,1 Internal Medicine I, Division of Infectious Diseases and Chemotherapy,2 Medical and Chemical Laboratory Diagnosis,3 and Internal Medicine II, Division of Angiology,4 University of Vienna Medical School, Vienna, Austria

Received 20 November 1998/Returned for modification 17 April 1999/Accepted 25 May 1999

Interstitial ciprofloxacin concentrations were measured by microdialysis in inflamed foot lesions of non-insulin-dependent diabetes mellitus patients following intravenous administration of 0.2 g of ciprofloxacin. Interstitial ciprofloxacin concentrations were significantly lower than corresponding serum concentrations. There was no significant difference in the penetration of ciprofloxacin into inflamed and unaffected tissue (area under the concentration-time curveinfection/area under the concentration-time curveunaffected tissue = 0.99 ± 0.15 [mean ± standard error], n = 6). Thus, inflammation appears to have little or no effect on the penetration of ciprofloxacin into tissue.

* Corresponding author. Mailing address: Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, Allgemeines Krankenhaus, Währinger Gürtel 18-20, A-1090 Vienna, Austria. Phone: 43-1-40400-2981. Fax: 43-1-40400-2998. E-mail: markus.mueller{at}univie.ac.at.

Antimicrobial Agents and Chemotherapy, August 1999, p. 2056-2058, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Lipsky, B. A., Giordano, P., Choudhri, S., Song, J. (2007). Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/amoxicillin-clavulanate. J Antimicrob Chemother 60: 370-376 [Abstract] [Full Text]  
  • Skhirtladze, K., Hutschala, D., Fleck, T., Thalhammer, F., Ehrlich, M., Vukovich, T., Muller, M., Tschernko, E. M. (2006). Impaired Target Site Penetration of Vancomycin in Diabetic Patients following Cardiac Surgery.. Antimicrob. Agents Chemother. 50: 1372-1375 [Abstract] [Full Text]  
  • Langer, O., Karch, R., Muller, U., Dobrozemsky, G., Abrahim, A., Zeitlinger, M., Lackner, E., Joukhadar, C., Dudczak, R., Kletter, K., Muller, M., Brunner, M. (2005). Combined PET and Microdialysis for In Vivo Assessment of Intracellular Drug Pharmacokinetics in Humans. JNM 46: 1835-1841 [Abstract] [Full Text]  
  • Joukhadar, C., Dehghanyar, P., Traunmuller, F., Sauermann, R., Mayer-Helm, B., Georgopoulos, A., Muller, M. (2005). Increase of Microcirculatory Blood Flow Enhances Penetration of Ciprofloxacin into Soft Tissue. Antimicrob. Agents Chemother. 49: 4149-4153 [Abstract] [Full Text]  
  • Legat, F. J., Krause, R., Zenahlik, P., Hoffmann, C., Scholz, S., Salmhofer, W., Tscherpel, J., Tscherpel, T., Kerl, H., Dittrich, P. (2005). Penetration of Piperacillin and Tazobactam into Inflamed Soft Tissue of Patients with Diabetic Foot Infection. Antimicrob. Agents Chemother. 49: 4368-4371 [Abstract] [Full Text]  
  • Zeitlinger, M. A., Erovic, B. M., Sauermann, R., Georgopoulos, A., Muller, M., Joukhadar, C. (2005). Plasma concentrations might lead to overestimation of target site activity of piperacillin in patients with sepsis. J Antimicrob Chemother 56: 703-708 [Abstract] [Full Text]  
  • Lipsky, B. A., Berendt, A. R., Deery, H. G., Embil, J. M., Joseph, W. S., Karchmer, A. W., LeFrock, J. L., Lew, D. P., Mader, J. T., Norden, C., Tan, J. S. (2005). Diagnosis and Treatment of Diabetic Foot Infections. J. Am. Podiatr. Med. Assoc. 95: 183-210 [Full Text]  
  • Brunner, M., Langer, O., Dobrozemsky, G., Muller, U., Zeitlinger, M., Mitterhauser, M., Wadsak, W., Dudczak, R., Kletter, K., Muller, M. (2004). [18F]Ciprofloxacin, a New Positron Emission Tomography Tracer for Noninvasive Assessment of the Tissue Distribution and Pharmacokinetics of Ciprofloxacin in Humans. Antimicrob. Agents Chemother. 48: 3850-3857 [Abstract] [Full Text]  
  • Muller, M., dela Pena, A., Derendorf, H. (2004). Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue. Antimicrob. Agents Chemother. 48: 1441-1453 [Full Text]  
  • Swoboda, S., Oberdorfer, K., Klee, F., Hoppe-Tichy, T., von Baum, H., Geiss, H. K. (2003). Tissue and serum concentrations of levofloxacin 500 mg administered intravenously or orally for antibiotic prophylaxis in biliary surgery. J Antimicrob Chemother 51: 459-462 [Abstract] [Full Text]  
  • Brunner, M., Stass, H., Moller, J.-G., Schrolnberger, C., Erovic, B., Hollenstein, U., Zeitlinger, M., Eichler, H. G., Muller, M. (2002). Target Site Concentrations of Ciprofloxacin after Single Intravenous and Oral Doses. Antimicrob. Agents Chemother. 46: 3724-3730 [Abstract] [Full Text]  
  • Delacher, S., Derendorf, H., Hollenstein, U., Brunner, M., Joukhadar, C., Hofmann, S., Georgopoulos, A., Eichler, H. G., Muller, M. (2000). A combined in vivo pharmacokinetic-in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans. J Antimicrob Chemother 46: 733-739 [Abstract] [Full Text]  
  • Frossard, M., Joukhadar, C., Erovic, B. M., Dittrich, P., Mrass, P. E., Van Houte, M., Burgmann, H., Georgopoulos, A., Müller, M. (2000). Distribution and Antimicrobial Activity of Fosfomycin in the Interstitial Fluid of Human Soft Tissues. Antimicrob. Agents Chemother. 44: 2728-2732 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»