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Antimicrobial Agents and Chemotherapy, August 1999, p. 2059-2062, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro Activities of Linezolid against Important Gram-Positive Bacterial Pathogens Including Vancomycin-Resistant Enterococci

Gary A. Noskin,1,2,3,* Farida Siddiqui,2 Valentina Stosor,1,2,4 Donna Hacek,4 and Lance R. Peterson1,2,4

Division of Infectious Diseases, Department of Medicine,1 and Clinical Microbiology Division, Department of Pathology,2 Northwestern University Medical School, and Departments of Infection Control3 and Prevention and Clinical Microbiology,4 Northwestern Memorial Hospital, Chicago, Illinois

Received 21 December 1998/Returned for modification 29 April 1999/Accepted 18 May 1999

The emergence of resistance in gram-positive bacteria has necessitated a search for new antimicrobial agents. Linezolid is an oxazolidinone, a new class of antibacterial agents with enhanced activity against pathogens. We compared the activity of linezolid to those of other antimicrobial agents against 3,945 clinical isolates. Linezolid demonstrated potent activity against all isolates tested. For all vancomycin-susceptible enterococci, staphylococci, and streptococci, the activity of linezolid was comparable to that of vancomycin. Against oxacillin-resistant staphylococci and vancomycin-resistant enterococci, linezolid was the most active agent tested. In summary, linezolid appears to be a promising new antimicrobial agent for the treatment of gram-positive infections.

* Corresponding author. Mailing address: Northwestern University Medical School, Division of Infectious Diseases, 251 E. Huron St., Feinberg 16-704, Chicago, IL 60611. Phone: (312) 926-2729. Fax: (312) 926-7845. E-mail: gnoskin{at}nwu.edu.

Antimicrobial Agents and Chemotherapy, August 1999, p. 2059-2062, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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