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Antimicrobial Agents and Chemotherapy, September 1999, p. 2144-2147, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Prevalence and Mechanisms of Macrolide Resistance in Clinical Isolates of Group A Streptococci from Ontario, Canada

J. C. S. De Azavedo,1,2,* R. H. Yeung,3 D. J. Bast,1,2 C. L. Duncan,1 S. B. Borgia,1 and D. E. Low1,2

Department of Microbiology, Mount Sinai and Princess Margaret Hospitals,1 MDS Laboratories,3 and Department of Pathobiology and Laboratory Medicine, University of Toronto,2 Toronto, Ontario, Canada

Received 4 February 1999/Returned for modification 19 May 1999/Accepted 24 June 1999

A total of 3,205 group A streptoccal isolates were collected in 1997 through a private laboratory which serves community physicians in southern Ontario and which represents a population base of 6 million people. Nonsusceptibility to erythromycin was detected for 67 (2.1%) isolates both by disk diffusion and by broth microdilution. Of these, 47 (70%) were susceptible to clindamycin and were found by PCR to possess the mef gene. Of the other 20 strains, 18 and 2 showed inducible and constitutive resistance, respectively, to clindamycin. Nineteen of these strains were shown by PCR to possess the ermTR gene, and a single constitutively resistant strain harbored an ermB gene. Sixteen (24%) erythromycin-resistant strains were also resistant to tetracycline. All were susceptible to penicillin and chloramphenicol.

* Corresponding author. Mailing address: Department of Microbiology, 600 University Ave., Rm. 1483, Toronto, Ontario, Canada M5G 1X5. Phone: (416) 586-8549. Fax: (416) 586-8746. E-mail: jdeazavedo{at}mtsinai.on.ca.

Antimicrobial Agents and Chemotherapy, September 1999, p. 2144-2147, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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