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Antimicrobial Agents and Chemotherapy, September 1999, p. 2299-2301, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro Activities of Fluoroquinolones against Antibiotic-Resistant Blood Culture Isolates of Viridans Group Streptococci from across Canada

J. C. S. de Azavedo,* L. Trpeski, S. Pong-Porter, S. Matsumura, The Canadian Bacterial Surveillance Network,dagger and D. E. Low

Department of Microbiology, Mount Sinai and Princess Margaret Hospitals, and Department of Pathobiology and Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada

Received 5 January 1999/Returned for modification 3 March 1999/Accepted 6 July 1999

Among 418 blood culture isolates of viridans group streptococci obtained between 1995 and 1997, the in vitro rates of nonsusceptibility to penicillin, erythromycin, tetracycline, and trimethoprim-sulfamethoxazole were 28, 29, 24, and 14%, respectively. The most prevalent group (125 strains) was Streptococcus mitis, followed by Streptococcus sanguis (56 strains). For 236 (56%) strains resistant to one or more antibiotics, the ciprofloxacin MIC at which 90% of the isolates were inhibited (MIC90) was 4 µg/ml, whereas the MIC90s of trovafloxacin, grepafloxacin, and gatifloxacin were 0.25 µg/ml.

* Corresponding author. Mailing address: Department of Microbiology, 600 University Ave., Rm. 1483, Toronto, Ontario, Canada M5G 1X5. Phone: (416) 586-8549. Fax: (416) 586-8746. E-mail: jdeazavedo{at}mtsinai.on.ca.

dagger Members are listed in the appendix.

Antimicrobial Agents and Chemotherapy, September 1999, p. 2299-2301, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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