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Antimicrobial Agents and Chemotherapy, September 1999, p. 2302-2304, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Mononuclear and Polymorphonuclear Leukocyte Dispositions of Clarithromycin and Azithromycin in AIDS Patients Requiring Mycobacterium avium Complex Prophylaxis

Khanh Q. Bui,1 JoCarol McNabb,1 Chonghua Li,1 Charles H. Nightingale,2 and David P. Nicolau1,3,*

Department of Pharmacy Research,1 Department of Research Administration,2 and Department of Medicine, Division of Infectious Diseases,3 Hartford Hospital, Hartford, Connecticut 06102

Received 4 January 1999/Returned for modification 24 May 1999/Accepted 17 June 1999

The intracellular dispositions of clarithromycin and azithromycin in AIDS patients requiring Mycobacterium avium complex (MAC) prophylaxis were studied. The dispositions of both drugs in mononuclear and polymorphonuclear leukocytes were markedly different. Our data support the proven efficacy of these agents for MAC prophylaxis since clarithromycin and azithromycin displayed sustained intracellular concentrations which exceeded their MICs for MAC throughout the dosing periods.

* Corresponding author. Mailing address: Department of Research Administration, Hartford Hospital, 80 Seymour St., Box 5037, Hartford, CT 06102. Phone: (860) 545-3941. Fax: (860) 545-5112. E-mail: dnicola{at}harthosp.org.

Antimicrobial Agents and Chemotherapy, September 1999, p. 2302-2304, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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