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Antimicrobial Agents and Chemotherapy, September 1999, p. 2305-2306, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Lack of In Vitro Antimicrosporidian Activity of Thalidomide

Olivier Ridoux and Michel Drancourt*

Unité des Rickettsies, CNRS UPRES-A 6020, Faculté de Médecine, Université de la Méditerranée, Marseille, France

Received 26 April 1999/Returned for modification 27 May 1999/Accepted 24 June 1999

Thalidomide was evaluated for its in vitro activity against Encephalitozoon species by using the MRC-5 cell system. A cytotoxic effect was observed for concentrations of 101 µg/ml (P < 105) and 5 µg/ml (P < 105). Thalidomide did not significantly inhibit the growth of any of the microsporidia under study. These data suggest that thalidomide is not an etiologic treatment in microsporidial enteritis.

* Corresponding author. Mailing address: Unité des Rickettsies, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France. Phone: 33 (0) 4.91.32.43.75. Fax. 33 (0) 4.91.83.03.90. E-mail: Michel.Drancourt{at}medecine.univ-mrs.fr.

Antimicrobial Agents and Chemotherapy, September 1999, p. 2305-2306, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Tadesse, A., Shannon, E. J. (2005). Effects of Thalidomide on Intracellular Mycobacterium leprae in Normal and Activated Macrophages. CVI 12: 130-134 [Abstract] [Full Text]  
  • Nasca, M. R, Micali, G., Cheigh, N. H, West, L. E, West, D. P (2003). Dermatologic and Nondermatologic Uses of Thalidomide. The Annals of Pharmacotherapy 37: 1307-1320 [Abstract] [Full Text]  


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