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Antimicrobial Agents and Chemotherapy, January 2000, p. 169-172, Vol. 44, No. 1
Pharmazeutische Mikrobiologie, University of
Bonn, 53115 Bonn, Germany
Received 5 April 1999/Returned for modification 27 June
1999/Accepted 15 October 1999
Penicillin-binding proteins (PBPs) are involved in the regulation
of
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Role of Penicillin-Binding Proteins in the
Initiation of the AmpC
-Lactamase Expression in
Enterobacter cloacae
-lactamase expression by determining the level of
anhydromuramylpeptides in the periplasmatic space. It was hypothesized
that one or more PBPs act as a sensor in the
-lactamase induction
pathway. We have performed induction studies with Escherichia
coli mutants lacking one to four PBPs with
DD-carboxypeptidase activity. Therefore, we conclude that a
strong
-lactamase inducer must inhibit all DD-carboxypeptidases as well as the essential PBPs 1a, 1b,
and/or 2.
*
Corresponding author. Mailing address:
Pharmazeutische Mikrobiologie, University of Bonn, Meckenheimer Allee
168, 53115 Bonn, Germany. Phone: (0228) 735272. Fax: (0228)
735267. E-mail: b.wiedemann{at}uni-bonn.de.
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