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Antimicrobial Agents and Chemotherapy, January 2000, p. 169-172, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Role of Penicillin-Binding Proteins in the Initiation of the AmpC beta -Lactamase Expression in Enterobacter cloacae

Dieter Pfeifle, Eva Janas, and Bernd Wiedemann*

Pharmazeutische Mikrobiologie, University of Bonn, 53115 Bonn, Germany

Received 5 April 1999/Returned for modification 27 June 1999/Accepted 15 October 1999

Penicillin-binding proteins (PBPs) are involved in the regulation of beta -lactamase expression by determining the level of anhydromuramylpeptides in the periplasmatic space. It was hypothesized that one or more PBPs act as a sensor in the beta -lactamase induction pathway. We have performed induction studies with Escherichia coli mutants lacking one to four PBPs with DD-carboxypeptidase activity. Therefore, we conclude that a strong beta -lactamase inducer must inhibit all DD-carboxypeptidases as well as the essential PBPs 1a, 1b, and/or 2.

* Corresponding author. Mailing address: Pharmazeutische Mikrobiologie, University of Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany. Phone: (0228) 735272. Fax: (0228) 735267. E-mail: b.wiedemann{at}uni-bonn.de.

Antimicrobial Agents and Chemotherapy, January 2000, p. 169-172, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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