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Antimicrobial Agents and Chemotherapy, January 2000, p. 183-185, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

A Nine-Codon Deletion Mutation in the Cytomegalovirus UL97 Phosphotransferase Gene Confers Resistance to Ganciclovir

Sunwen Chou* and Camie L. Meichsner

Medical and Research Services, Veterans Affairs Medical Center, and Division of Infectious Diseases, Oregon Health Sciences University, Portland, Oregon

Received 21 June 1999/Returned for modification 13 August 1999/Accepted 11 October 1999

A deletion mutation (codons 595 to 603) in the cytomegalovirus (CMV) UL97 gene was recently reported after sequence analysis of leukocyte DNA from a patient receiving ganciclovir. The corresponding viral phenotype was examined by transfer of this mutation to a laboratory CMV strain (strain Towne). The recombinant virus was resistant to ganciclovir (8.4-fold increase in the 50% inhibitory concentration), was sensitive to foscarnet, and replicated normally in cell culture.

* Corresponding author. Mailing address: Infectious Disease Section P3ID, VA Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97201. Phone: (503) 273-5185. Fax: (503) 273-5348. E-mail: chous{at}ohsu.edu.

Antimicrobial Agents and Chemotherapy, January 2000, p. 183-185, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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