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Antimicrobial Agents and Chemotherapy, January 2000, p. 200-204, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Delta 12-Prostaglandin J2 Is a Potent Inhibitor of Influenza A Virus Replication

Francesca Pica,1 Anna Teresa Palamara,1 Antonio Rossi,2,3 Alessandra De Marco,2 Carla Amici,1 and M. Gabriella Santoro2,3,*

Departments of Experimental Medicine1 and Biology,2 University of Rome Tor Vergata, and Institute of Experimental Medicine,3 CNR, Rome, Italy

Received 8 February 1999/Returned for modification 13 May 1999/Accepted 18 October 1999

9-Deoxy-Delta 9,Delta 12-13,14-dihydro-prostaglandin D2 (Delta 12-PGJ2), a natural cyclopentenone metabolite of prostaglandin D2, is shown to possess therapeutic efficacy against influenza A virus A/PR8/34 (H1N1) infection in vitro and in vivo. The results indicate that the antiviral activity is associated with induction of cytoprotective heat shock proteins and suggest novel strategies for treatment of influenza virus infection.

* Corresponding author. Mailing address: Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Roma RM, Italy. Phone: 39-06-7259-4764/4822. Fax: 39-06-7259-4821. E-mail: santoro{at}bio.uniroma2.it.

Antimicrobial Agents and Chemotherapy, January 2000, p. 200-204, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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