Antimicrobial Agents and Chemotherapy, January 2000, p. 226-229, Vol. 44, No. 1
Istituto di Malattie Infettive e Medicina
Pubblica, Università degli Studi di Ancona, Ancona,
Italy1; Fungus Testing Laboratory,
Department of Pathology, University of Texas Health Science Center, San
Antonio, Texas 72284-77502; Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas
78284-51003
Received 7 June 1999/Returned for modification 16 September
1999/Accepted 25 October 1999
A broth microdilution method performed in accordance with the
National Committee for Clinical Laboratory Standards guidelines was
used to compare the in vitro activity of the new antifungal triazole
SCH 56592 (SCH) to that of fluconazole (FLC), itraconazole (ITC), and
ketoconazole (KETO) against 257 clinical yeast isolates. They included
220 isolates belonging to 12 different species of Candida,
15 isolates each of Cryptococcus neoformans and
Saccharomyces cerevisiae, and seven isolates of
Rhodotorula rubra. The MICs of SCH at which 50%
(MIC50) and 90% (MIC90) of the isolates were inhibited were 0.06 and 2.0 µg/ml, respectively. In general, SCH was
considerably more active than FLC (MIC50 and
MIC90 of 1.0 and 64 µg/ml, respectively) and slightly
more active than either ITC (MIC50 and MIC90 of
0.25 and 2.0 µg/ml, respectively) and KETO (MIC50 and
MIC90 of 0.125 and 4.0 µg/ml, respectively). Our in vitro
data suggest that SCH has significant potential for clinical development.
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
In Vitro Activities of the New Antifungal Triazole
SCH 56592 against Common and Emerging Yeast Pathogens
*
Corresponding author. Mailing address: Istituto di
Malattie Infettive e Medicina Pubblica, Università degli Studi di
Ancona, Ospedale Umberto I°, Largo Cappelli 1, 60121, Ancona,
Italy. Phone: 39.71.5963467. Fax: 39.71.5963468. E-mail:
cmalinf{at}popcsi.unian.it.
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