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Antimicrobial Agents and Chemotherapy, January 2000, p. 24-29, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

MICs of Mutacin B-Ny266, Nisin A, Vancomycin, and Oxacillin against Bacterial Pathogens

Marilaine Mota-Meira,1 Gisèle Lapointe,1 Christophe Lacroix,1 and Marc C. Lavoie2,*

Centre de Recherche en Sciences et Technologie du Lait (STELA), Faculté des Sciences de l'Agriculture et de l'Alimentation,1 and Département de Biochimie, Faculté de Sciences et Génie,2 Université Laval, Cité Universitaire, Québec, Québec, Canada G1K 7P4

Received 3 February 1999/Returned for modification 31 May 1999/Accepted 10 October 1999

Peptide antibiotics, particularly lantibiotics, are good candidates for replacing antibiotics to which bacteria have become resistant. In order to compare two such lantibiotics with two antibiotics, the MICs of nisin A, mutacin B-Ny266, vancomycin, and oxacillin against various bacterial pathogens were determined. The results indicate that nisin A and mutacin B-Ny266 are as active as vancomycin and oxacillin against most of the strains tested. Furthermore, mutacin B-Ny266 remains active against strains that are resistant to nisin A, oxacillin, or vancomycin. The wide spectrum of activity of mutacin B-Ny266, its low MICs against bacterial pathogens, and its activity against bacteria resistant to other inhibitors support the development of this substance for therapeutic use.

* Corresponding author. Mailing address: Département de Biochimie, Faculté de Sciences et Génie, Université Laval, Cité Universitaire, Québec, Québec, Canada G1K 7P4. Phone: (418) 656-2131, ext. 2151. Fax: (418) 656-3664. E-mail: Marc.Lavoie{at}bcm.ulaval.ca.

Antimicrobial Agents and Chemotherapy, January 2000, p. 24-29, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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